Joshua Rabinowitz

Joshua Rabinowitz is a Professor of Chemistry and Director of the Ludwig Princeton Branch at Princeton University. His research focuses on quantitative analysis of cellular metabolism, leveraging advanced mass spectrometry and computational modeling. Key areas include metabolic regulation in microbes (E. coli, yeast), cancer cell metabolism, viral infection impacts, and biofuel production. His lab has pioneered methods to measure metabolites and fluxes, leading to discoveries like novel cancer metabolites and antiviral strategies via fatty acid inhibition. Notable honors include the NIH Pioneer Award and Agilent Thought Leader Award.

Research emphasizes systems-level understanding, with projects combining biological experiments, metabolomics, and computation. Recent work explores metabolic heterogeneity in humans, immunotherapy enhancements through metabolic modulation, and metabolic vulnerabilities in cancers like rhabdomyosarcoma. Collaborations include engineering yeast for biofuel production and developing therapeutics targeting metabolic pathways.

• Lab Website: Rabinowitz Lab
• Affiliations: Lewis-Sigler Institute for Integrative Genomics, Princeton University

Major contributions include identifying metabolic shifts in viral infections, modeling microbial nutrient responses, and advancing technologies for metabolite quantification. Current efforts aim to integrate metabolomic data with enzyme regulation dynamics to predict metabolic networks across organisms.