Joshua J. Chiappelli

Joshua J. Chiappelli is an Assistant Professor in the Department of Psychiatry at the University of Maryland School of Medicine, affiliated with the Maryland Psychiatric Research Center (MPRC). He maintains clinical practice at the Fayette Adult Clinic of the Walter P. Carter Center and the First Episode Clinic at MPRC, specializing in severe mental illness with a focus on schizophrenia.

Dr. Chiappelli's educational background includes:

• B.A. in Psychology from St. Mary’s College of Maryland (2004)
• M.D. from Drexel University College of Medicine (2008)
• Psychiatry Residency at University of Maryland / Sheppard Pratt (2008-2012)

His research centers on white matter structural abnormalities in schizophrenia and their relationship to cognitive deficits and treatment resistance. Employing diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS), he investigates white matter plasticity, bioenergetics, and the phenomenology of psychotic symptoms, with particular emphasis on biomarker discovery through tryptophan metabolism, kynurenic acid pathways, and cardiovascular risk interactions.

Analysis of his 2014-2023 publications reveals consistent investigation of schizophrenia pathophysiology through multimodal neuroimaging and biochemical approaches. Key trends include the role of white matter integrity in cognitive deficits, stress-induced biomarker alterations (kynurenic acid, myo-Inositol), and cardiovascular-brain interactions. His work increasingly integrates phenomenological frameworks with neuroscience to understand psychosis progression.

Information regarding Dr. Chiappelli's student advising and research grants was not provided in the available text.

As a core researcher at the Maryland Psychiatric Research Center, Dr. Chiappelli contributes to MPRC's mission as a leading institution for severe mental illness research, particularly through its schizophrenia-focused programs and advanced neuroimaging facilities.