Joshua C. Sandquist

Joshua C. Sandquist is an Associate Professor and Department Chair of Biology at Grinnell College. He leads research in cell division mechanisms using the African clawed frog (Xenopus laevis) as a model system. His work focuses on the coordination between mitotic spindle orientation and anaphase timing in epithelial cells, with implications for tissue organization and cancer metastasis. The Sandquist lab employs molecular, biochemical, and live-cell imaging approaches to study these processes.

Research emphasizes spindle dynamics in vertebrate embryos, linking cellular mechanics to developmental outcomes. Key projects investigate how spindle positioning influences division orientation and how this process is regulated by proteins like Wee1 and myosin-10. Current efforts aim to define mechanisms coordinating spindle alignment with cell cycle progression.

No scientific awards were explicitly listed in the provided text. The Sandquist lab collaborates across departments including Biological Chemistry and Science, Medicine, and Society. No student advisees or grant details were specified in the profile. The lab's work is centered at Grinnell College's Biology Department laboratories.