Joseph M Castellano

Joseph M. Castellano is an Associate Professor in Neuroscience and Neurology at the Icahn School of Medicine at Mount Sinai. His research focuses on molecular mechanisms underlying aging and Alzheimer's disease (AD) pathogenesis, particularly the role of blood-CNS interactions in regulating synaptic and neuroimmune function.

• PhD from Washington University in St. Louis
• Postdoctoral training at Stanford University

His work spans several key areas: Aging, Alzheimer's Disease, Microglia, Immunology, and Stem Cells. Notable contributions include demonstrating how APOE4 impedes amyloid-beta clearance and identifying youth-associated peripheral factors like TIMP2 that reverse brain aging.

Recent publications highlight his exploration of neuroimmune regulation via blood-borne factors, proteomic changes linked to APOE genotype, and therapeutic strategies targeting aging-associated conditions. His lab employs advanced techniques like microdialysis and in vivo imaging to study these mechanisms.

• 2021 ISMMS ADRC Developmental Project Grant
• 2020 Black Family Stem Cell Institute Pilot Award
• 2018 Katz and Martin Friedman Brain Institute Research Scholar
• 2016 K99/R00 Pathway to Independence Award (NIA/NIH)

Dr. Castellano's research bridges fundamental aging biology with translational neurodegeneration studies, supported by grants from NIH and private foundations. His lab continues to investigate how systemic factors influence brain health, aiming to develop novel AD interventions.