Jordan P. Metcalf

Jordan P. Metcalf, M.D., is a Professor of Medicine in the Department of Medicine at the University of Oklahoma Health Sciences Center (OUHSC), affiliated with the Pulmonary, Critical Care & Sleep Medicine Section within the School of Medicine. He leads an active research laboratory focused on innate immune responses to respiratory pathogens.

Education:

• M.D., University of Nebraska College of Medicine, 1984
• Residency, Internal Medicine, University of Nebraska Medical Center, 1984–1988
• Pulmonary and Critical Care Fellowship, University of Nebraska Medical Center, 1988–1991
• Research Fellowship, University of Iowa, 1991–1993

Research Interests:
Jordan Metcalf's research centers on understanding how the human lung responds to infectious agents such as influenza virus, adenovirus, and Bacillus anthracis at the cellular and molecular level. His lab employs human lung organ culture and primary cell models to investigate host-pathogen interactions, with a particular focus on how cigarette smoke exposure impairs antiviral immunity and increases susceptibility to respiratory infections, including influenza and SARS-CoV-2. His work has significantly contributed to understanding immune evasion mechanisms and the pathogenesis of respiratory diseases.

Publication Trends:
His recent publications reveal a sustained focus on innate immunity in the lung, particularly the role of RIG-I and other pattern recognition receptors in antiviral defense. A recurring theme is the detrimental impact of cigarette smoke on these immune pathways, increasing vulnerability to viral infections. His research also extends to bacterial pathogens like B. anthracis, examining toxin effects and spore dissemination in human lung models.

Scientific Awards:
No specific awards were mentioned in the provided text.

Advising and Grants:
Dr. Metcalf leads a research team including a Research Assistant Professor, Research Assistants, a Research Fellow, and a Research Technician. While specific grant funding is not detailed, his sustained research output and laboratory operations suggest active grant support. He has held the position of Research Director in his section since 2014, indicating leadership in research strategy and mentorship.

Labs and Teams:
He directs the Dr. Jordan Metcalf Lab, which is part of the Basic Science Research division in the Pulmonary, Critical Care & Sleep Medicine Section. The lab team includes Dr. Wenxin Wu (Research Assistant Professor), Lee Booth, Wei Zhang, Lili Tian, and Jeremy Alexander, working collaboratively on projects related to innate immunity and respiratory infections.