Jonathan Angel

Jonathan Angel is a Professor at the University of Ottawa and Senior Scientist at The Ottawa Hospital Research Institute, specializing in HIV research. He leads translational studies focused on immune dysfunction during HIV infection and develops antiretroviral, immune-mediated, and oncolytic virus-based treatments for potential HIV cures.

Research Interests

His work bridges Microbiology, Immunology, and Virology, with emphasis on:

• Immune dysfunction mechanisms in HIV
• Oncolytic virus therapy for HIV reservoir elimination
• Antimicrobial peptides as anti-HIV agents
• SMAC Mimetics in HIV treatment
• Translational approaches to HIV cure

Scientific Contributions

Recent publications highlight:

• LL-37 safety in reproductive tract administration (2023)
• SMAC Mimetics in HIV therapy (2021)
• LL-37's anti-HIV potential (2021)
• MG1 virus targeting HIV-infected macrophages (2021)
• Foundational work on MG1 for HIV cure (2018)

Awards

• Tier 1 Clinical Research Chair