John Prensner
Assistant Professor · Childhood Brain Tumors
University of Michigan-Ann ArborUnited States
About
John Prensner is an Assistant Professor in the Department of Pediatrics - Hematology Oncology at the University of Michigan. He is a physician-scientist and pediatric hematologist/oncologist specializing in childhood brain tumors, particularly medulloblastoma and diffuse intrinsic pontine glioma.
- Education: Tufts University (BS 2005), University of Michigan (MD/PhD 2014)
- Clinical training: Boston Combined Residency, Boston Children's Hospital/Dana-Farber Cancer Institute fellowship
- Postdoctoral research: Broad Institute of MIT and Harvard
His research focuses on:
- Molecular mechanisms of childhood brain cancers
- Synthetic lethality in cancer genomics
- Metabolic dependencies in Group-3 medulloblastoma
- Non-canonical RNA translation and microproteins in oncogenesis
- CRISPR screening for therapeutic targets
Recent work highlights PELO as a synthetic lethal target in 5% of adult cancers and metabolic vulnerabilities in medulloblastoma, including cuproptosis mechanisms.
Collaborations include:
- @LyssiotisLab (metabolism)
- @vennetilab
- @CancerDepMap
- Carl Koschmann
- Paul Northcott
- Deepak Nagrath
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