John C. Lieske

John C. Lieske, M.D., is a Professor of Medicine and Consultant in Nephrology & Hypertension at Mayo Clinic. He holds appointments in multiple departments, including Physiology & Biomedical Engineering and Laboratory Medicine and Pathology. His research focuses on kidney stone formation mechanisms, renal tubular biology, and genetic disorders like primary hyperoxaluria. Dr. Lieske leads projects funded by NIH, investigating nephrolithiasis pathogenesis, Dent Disease, and stone prevention strategies. He serves on key advisory boards, including the Oxalosis and Hyperoxaluria Foundation and NIH Study Sections. His work bridges clinical practice and translational research, aiming to improve treatments for kidney diseases.

• Education: MD from University of Chicago, BS in Biomedical Engineering from Northwestern University.
• Research Interests: Crystal adhesion to renal cells, Tamm-Horsfall protein role, nanobacteria in calcification, genetic risk factors, and clinical trials for hyperoxaluria treatments.
• Grants/Projects: NIH-funded studies on nephrolithiasis biobanking, renal stone precursor lesions, and Dent Disease natural history.
• Publications: Over 400 peer-reviewed articles, emphasizing kidney stone epidemiology, genetic etiologies, and therapeutic advancements.

Dr. Lieske's contributions span academic leadership, including presidencies of the ROCK Society and roles in Mayo's Polycystic Kidney Disease Center. His research impacts prevention strategies for chronic kidney disease and nephrolithiasis complications.