Joey Sheff

Dr. Joey Sheff is an Adjunct Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa Faculty of Medicine. He also serves as an Associate Research Officer at the National Research Council of Canada's Human Health Therapeutics division. His work bridges structural proteomics, mass spectrometry, and protein chemistry with applications in antibody-antigen interactions and therapeutic development.

• PhD, University of Calgary (2017)
• Postdoctoral Fellowship, NRC Canada (2017-2020)

Dr. Sheff specializes in structural proteomics platforms for studying protein interactions, particularly through hydrogen-deuterium exchange and cross-linking mass spectrometry techniques. His research focuses on:

• Biophysical characterization of protein complexes
• Therapeutic antibody mechanisms in cancer and immunotherapy
• Structural analysis of proteins in emerging infections

His publications highlight expertise in protein dynamics, antibody engineering, and mass spectrometry methodology. Notable work includes structural studies of SARS-CoV-2 neutralization nanobodies and antibody-antigen interactions for blood-brain barrier crossing.