Jochen Buck

Jochen Buck is a Professor in the Department of Pharmacology at Weill Cornell Medicine. His research focuses on bicarbonate-regulated soluble adenylyl cyclase (sAC), a key enzyme in cAMP signaling pathways. sAC serves as a physiological sensor for CO₂/bicarbonate/pH, with roles in diverse processes including sperm capacitation, lysosomal acidification, and metabolic regulation. He collaborates extensively with Dr. Lonny Levin's laboratory, contributing to drug discovery efforts targeting sAC for contraception and disease intervention.

• Key Research Areas: cAMP signaling, CO₂/pH sensing, bioenergetics, reproductive biology, cancer metabolism
• Notable Contributions: Cloning of sAC, identification of sAC inhibitors (LRE1, Bithionol), elucidation of sAC's role in sperm function and lysosomal pH regulation

His recent work emphasizes therapeutic targeting of sAC through inhibitor development, metabolic regulation in sperm capacitation, and the enzyme's role in tumor suppression. Publications span journals like Frontiers in Physiology, Journal of Medicinal Chemistry, and Science Signaling.