Jim Haseloff

Professor Jim Haseloff is a faculty member at the University of Cambridge, serving as Head of the Synthetic Biology for Engineering Plant Growth Group within the Department of Plant Sciences, School of Biological Sciences. His research focuses on applying engineering principles to construct new genetic systems in plants, with particular emphasis on using Marchantia polymorpha as a model system for understanding and engineering plant growth and development.

Professor Haseloff's research interests span synthetic biology, genetic circuit design, plant transformation technologies, and the development of low-cost tools for biological research. His laboratory develops novel DNA tools and imaging techniques for visualizing, manipulating, and modeling genetic interactions and morphogenesis in plants. His work bridges the gap between fundamental plant biology and applied engineering approaches to reprogram plant development and physiology. The lab has established Marchantia polymorpha as a simplified model system with a streamlined genome, haploid genetics, and an open form of development ideal for quantitative analysis.

Analysis of Professor Haseloff's recent publications reveals a strong focus on advancing the Marchantia model system for synthetic biology applications. His work spans genetic tool development, chloroplast engineering, plant sensing technologies, and fundamental developmental processes. Notably, his research increasingly integrates low-cost sensing technologies with traditional plant biology, reflecting his commitment to making synthetic biology more accessible worldwide.

Professor Haseloff is actively involved in several major initiatives including OpenPlant (promoting open technologies for plant synthetic biology), Biomaker (funding construction of low-cost devices for biology), and the Engineering Biology IRC. He has taught undergraduate courses on Plant and Microbial Sciences (NST PMS 1B), Plant Development (NST CDB 1B), and Synthetic Biology (NST PS 2), with extensive teaching materials publicly available online.

His laboratory has pioneered techniques for cell-free expression systems that are 200-400 times cheaper than commercial versions, low-cost microreactors using 3D-printed components, and innovative in vivo plant sensing devices. The group has developed extensive resources for the plant synthetic biology community, including standardized DNA parts, microscopy techniques, and educational materials for no-code programming in biology.