Jesse R. Dixon

Jesse R. Dixon, M.D., Ph.D., is an Associate Professor at the Gene Expression Laboratory of the Salk Institute for Biological Studies in La Jolla, California. His research explores 3D genome architecture, chromatin organization, and gene regulation mechanisms, with implications for cancer and developmental disorders. He employs cutting-edge genomic technologies like Hi-C and single-cell multi-omics to investigate how chromosomal rearrangements impact gene expression.

Dr. Dixon's work focuses on:

• Topological Domains (TADs) and their role in enhancer-promoter communication
• Haplotype phasing using chromatin conformation data
• Structural variant-driven oncogene activation in cancer
• Single-cell mapping of chromatin and DNA methylation dynamics

His publications consistently demonstrate innovations in 3D genome analysis, particularly in neurobiology and oncology contexts, with recurring themes of chromatin topology, epigenetic regulation, and computational genomics.

Awards & Honors:

• Pew Biomedical Scholar (2024)
• Helmsley Salk Fellow

He mentors graduate and postdoctoral researchers in genomics and computational biology, with current projects on chromatin dynamics in cancer and development. The Dixon Lab actively develops novel methodologies for studying genome architecture.