Jennifer O. Manilay

Jennifer O. Manilay is a Professor at the University of California, Merced, affiliated with the School of Natural Sciences and the Quantitative and Systems Biology Graduate Program. Her research explores the intersection of immune system development, stem cell biology, and developmental biology using mouse models.

• University: University of California, Merced
• School: School of Natural Sciences
• Program Affiliation: Quantitative and Systems Biology Graduate Program

Her laboratory investigates mechanisms of immune system development, focusing on:

• Bone marrow microenvironment dynamics
• Stress erythropoiesis and B cell lymphopoiesis
• NK cell Ly-49 developmental pathways
• Wnt antagonists in hematopoietic cell fate
• Sclerostin's role in inflammation and osteoporosis therapies

Recent publications highlight how Vhl deletion in Dmp1-expressing cells impacts MEP metabolism and B cell development, alongside Sclerostin depletion studies in bone marrow inflammation. These works reflect her lab's emphasis on molecular regulation of immune and stem cell processes.

Scientific awards include:

• CIRM New Faculty Award

The lab, established in 2005, collaborates with investigators in immunology, hematology, and developmental biology. It trains graduate and undergraduate students in stem cell research and has contributed to understanding immune cell fate decisions and metabolic regulation.