Jennifer Golden

Jennifer Golden is an Associate Professor in the Department of Pharmaceutical Sciences at the School of Pharmacy, University of Wisconsin-Madison. Her research focuses on synthetic medicinal chemistry to develop novel antiviral and anti-parasitic agents for diseases like alphavirus infections and kinetoplastid parasites. The Golden Lab emphasizes chemical methodology development and structure-activity relationship analysis through collaborations assessing compound efficacy in cell and animal models.

Research Projects

• Quinazolinone Rearrangement: Developing synthetic transformations for amidine formation and ring-fused scaffolds.
• Anti-Alphaviral Agents: Creating FDA-approved therapeutic candidates for mosquito-borne RNA viruses.
• Broad-Spectrum Antiparasitics: Optimizing compounds for malaria, African sleeping sickness, and leishmaniasis.

Publications highlight her work on ML336 (anti-VEEV), quinazolinone derivatives, and collaborations with experts in high-throughput screening and structural biology. Her lab trains students in hit-to-lead optimization, regioselective synthesis, and medicinal chemistry tactics.

Education:

• B.S. (1996) – Eastern Illinois University
• Ph.D. (2002) – University of Kansas
• Postdoctoral Research (2004) – Stanford University