Jeff Dong

Jeff Dong is an Assistant Professor in the Department of Biochemistry, Microbiology & Immunology at the University of Saskatchewan. His research focuses on macrophage biology, neuroimmunology, and oxidized phosphatidylcholines' role in disease and aging.

• Education: PhD (2018) and BSc (2012) in Microbiology and Immunology from the University of British Columbia
• Postdoctoral Training: 2018-2022 at the University of Calgary in Clinical Neurosciences

Research interests center on:

• Microglia function in central nervous system homeostasis and disease
• Oxidized phosphatidylcholines (OxPC) as inflammatory mediators in multiple sclerosis and neurodegeneration
• Age-related macrophage dysfunction in tissue repair and fibrosis
• Phagocytic receptor signaling (e.g., TREM2) in lipid clearance
• Translational approaches to develop OxPC-targeting therapeutics

Recent publications highlight his work on OxPCs in neurodegenerative diseases, microglia responses across aging, and immune-modulating properties of extracellular matrix components like versican. His lab employs in vitro, in vivo, and translational methodologies to study these processes.