Jean-Philippe Gratton

Jean-Philippe Gratton is a Full Professor and Director of the Department of Pharmacology and Physiology at the Université de Montréal's Faculty of Medicine. He heads the Endothelial Cell Biology Unit at the Montreal Clinical Research Institute (IRCM), a position he has held since 2002. His dual appointments reflect his significant contributions to both academic medicine and clinical research in vascular biology.

Dr. Gratton earned his Bachelor's degree in Biochemistry (1992), followed by a Master's (1995) and Doctorate (1998) in Pharmacology, all from the University of Sherbrooke. He completed his post-doctoral training at Yale University School of Medicine in 2002, establishing the foundation for his career in vascular biology research.

His research focuses on endothelial cell biology, particularly the cellular mechanisms controlling endothelial cell proliferation, survival, and differentiation. Using molecular and cellular biology techniques combined with modern pharmacology, Dr. Gratton investigates intracellular signaling of endothelial growth factors, especially VEGF receptor dynamics and their influence on nitric oxide release. His work spans cardiovascular diseases and tumor angiogenesis, with particular interest in plasma membrane lipid microdomains, eNOS regulation, and endothelial dysfunction. His laboratory's findings have significant implications for understanding both vascular health and cancer progression.

Analysis of his recent publications reveals a consistent research trajectory centered on endothelial cell signaling mechanisms, with increasing focus on the intersection between vascular biology and cancer immunology. His work demonstrates how endothelial signaling pathways influence tumor microenvironments and can be targeted to improve cancer therapies, particularly through modulation of AXL receptor signaling and angiogenic processes.

• Université de Montréal Research Chair in Endothelial Cell Signaling and Angiogenesis (2013-present)
• Merck Canada Chair in Pharmacology at the University of Montreal

Dr. Gratton leads a productive research program with consistent funding and numerous collaborations across institutions. His laboratory serves as a training ground for the next generation of vascular biologists and pharmacologists, contributing significantly to understanding endothelial cell function in health and disease. The Endothelial Cell Biology Unit at IRCM maintains state-of-the-art facilities for molecular and cellular analysis of vascular processes.