Jean-Marc Ghigo

Prof. Jean-Marc Ghigo is a leading researcher at the Institut Pasteur, Paris, affiliated with the Department of Microbiology and head of the Genetics of Biofilms Laboratory. He leads multiple research projects focused on biofilm formation, physiology, and resistance mechanisms in pathogenic and commensal bacteria.

• Institution: Institut Pasteur
• School: Department of Microbiology
• Department: Genetics of Biofilms Laboratory
• Academic Rank: Professor
• Email: jmghigo@pasteur.fr

His research focuses on biofilm biology, bacterial genetics, antibiotic resistance, and microbial physiology. He investigates how bacteria form biofilms on surfaces, adapt metabolically, and resist antimicrobials, with a particular emphasis on Escherichia coli and Bacteroides thetaiotaomicron. His work includes studying anaerobic biofilms, volatile compounds, colonization resistance, and the development of genetic tools for biofilm research.

The recent publications reveal a strong trend in understanding molecular mechanisms of biofilm formation and resistance, including the role of efflux pumps, extracellular matrices, adhesins, and interspecies interactions. His studies span microbial physiology, structural biology, environmental microbiology, and host-microbe interactions, often using advanced techniques like liquid-cell electron microscopy and transcriptomic analysis.

He has not been explicitly associated with any scientific awards in the provided text.

Prof. Ghigo actively mentors students and postdoctoral researchers, including Yankel Chekli, Anne-Aurélie Lopes, Julie Le Bris, and others. His lab collaborates extensively within the Institut Pasteur and with external partners. He has developed widely used genetic tools and in vivo models for studying biofilms. His research is supported by institutional funding and collaborative grants, contributing to the development of novel strategies to combat biofilm-related infections.

His laboratory includes specialized spaces such as a biofilm room, zebrafish room, cell culture room, and microscopy facilities, enabling multidisciplinary research on bacterial communities and host interactions.