Jean-Christophe Lega

Jean-Christophe Lega is a Pharmacology researcher at University of Lyon leading the Modeling and Therapeutic Effect Modeling Team since January 2021. His work focuses on benefit-risk balance estimation and evidence-level assessment for antithrombotics and immunosuppressants through advanced meta-analytical methods.

His research spans baseline risk modeling, risk stratification, treatment effect interactions, subpopulation analysis, and personalized medicine applications. This has expanded into meta-research examining methodological and cognitive biases in treatment effect measurement, directly informing his work with the transparency commission of the French Haute Autorité de Santé (HAS).

Analysis of his 15 most recent publications reveals consistent expertise in meta-epidemiological studies (60% of works), with primary focus on pharmacovigilance (statin-associated muscle symptoms, bisphosphonate complications), autoimmune disease management (giant cell arteritis protocols, immune thrombocytopenia), and cardiovascular pharmacology (aspirin polypill simulations). Methodological themes center on publication bias quantification and risk-stratification modeling.

His scientific contributions include development of national clinical guidelines (giant cell arteritis protocol) and leadership of multicenter studies (STOPAGO long-term follow-up). Recent work features critical examination of compassionate-use drug outcomes during the COVID-19 pandemic.

• Lead researcher for Modeling and Therapeutic Effect Modeling Team (University of Lyon)
• Active member of Haute Autorité de Santé transparency commission
• Principal investigator for STOPAGO multicenter study on thrombopoietin receptor agonists
• Contributor to French national protocols for autoimmune disease management