Jay Ponder

Jay Ponder is Professor of Chemistry, Biochemistry and Molecular Biophysics, and Biomedical Engineering at Washington University in St. Louis. His research develops computational methods for structural biology and protein engineering, focusing on next-generation polarizable force fields (AMOEBA) for accurate prediction of molecular structures and interactions.

Research areas include molecular dynamics with multipole electrostatics, potential smoothing methods for conformational search, distance geometry algorithms for protein folding, and crystal structure prediction. The TINKER software package implements these computational approaches.

Ponder's group integrates high-performance computing with advanced algorithms for large-scale biomolecular simulations and free energy calculations.