Janelle Arthur

Janelle Arthur, PhD, is an Assistant Professor at the University of North Carolina at Chapel Hill School of Medicine in the Department of Microbiology & Immunology. Her research focuses on how inflammation-associated gut microbiota alterations influence neoplasia, fibrosis, and tissue remodeling in inflammatory bowel diseases (IBD).

• Affiliation: UNC School of Medicine, Center for Gastrointestinal Biology and Disease, Lineberger Comprehensive Cancer Center
• Research Methods: Microbiology, immunology, genomics, bioinformatics, gnotobiotic mouse models

Dr. Arthur's lab investigates the causal links between microbial genes and gastrointestinal diseases, particularly studying the role of Escherichia coli in Crohn's Disease-associated fibrosis and colitis-associated colorectal cancer. They employ DNA barcoding to track microbial strain dynamics in complex communities.

Key trends in her publications include microbiome-mediated disease mechanisms, probiotic engineering for therapeutic applications, and the role of bacterial metabolites like yersiniabactin in inflammation and fibrosis. Her work has implications for developing microbiota-targeted therapies.

• Scientific Award: Pilot and Feasibility Award (2013)

The Arthur Lab collaborates with researchers such as Carroll, Fodor, Furey, Sartor, Sheikh, Steinbach, Ting, and Wang. They utilize the National Gnotobiotic Rodent Resource Center and focus on microbial contributions to IBD comorbidities.