James D. Gorham

Dr. James D. Gorham is a Professor of Pathology at the University of Virginia School of Medicine, serving as Chief of the Division of Laboratory Medicine and Medical Director of the Transfusion Medicine Service. His clinical expertise spans Blood Banking, Transfusion Medicine, and Laboratory Medicine, where he applies his dual expertise in medicine and research to improve patient care and laboratory practices.

Dr. Gorham completed his MD/PhD at New York University (1985-1992), followed by residency training in Laboratory Medicine at Washington University School of Medicine / Barnes Hospital (1992-1998). This comprehensive training established the foundation for his career bridging clinical practice and scientific investigation.

His research program focuses on critical areas at the intersection of immunology and hematology:

• Factors affecting blood storage and transfusion outcomes
• Immune tolerance mechanisms and autoimmune processes
• Immunological functions specific to the liver microenvironment
• Mouse genetics applications for modeling human immune conditions

Dr. Gorham has established significant collaborative research with colleagues including Dr. John Luckey and Dr. James Zimring, developing novel murine models to investigate RBC metabolism, G6PD deficiency, and immune responses to blood group antigens. This work has positioned the University of Virginia as a recognized center for advancing knowledge in transfusion medicine and red blood cell immunology.

His scientific contributions demonstrate a consistent trajectory of high-impact research connecting basic immunological mechanisms with clinical applications. His publications reveal particular expertise in liver immunology, blood storage science, and the genetic basis of immune responses, with work appearing in prestigious journals including Proceedings of the National Academy of Sciences and Hepatology.

Dr. Gorham's professional service includes co-authoring the American Association for the Study of Liver Disease Practice Guidelines for autoimmune hepatitis, demonstrating his standing as a recognized expert in liver immunology who contributes to shaping clinical practice standards in the field.