James C. Garbutt
Professor · Addiction Medicine
University of North Carolina at Chapel HillAbout
James C. Garbutt, M.D. is a Professor in the Department of Psychiatry at the UNC School of Medicine, University of North Carolina at Chapel Hill, and a core member of the Addiction Clinical Trials (ACT) group focused on substance use disorder research.
His research centers on:
- Biological mechanisms of alcoholism
- Psychopharmacological treatment development
- Sweet preference-alcoholism correlation (65% of abstinent male alcoholics are "sweet likers")
- Clinical trials of baclofen and naltrexone for alcohol dependence
Recent publications (2014-2018) emphasize personalized pharmacotherapy approaches, examining naltrexone initiation protocols, sweet-liking biomarkers, and genetic factors influencing treatment efficacy in alcohol use disorder.
Dr. Garbutt leads ACT group initiatives including semaglutide trials for alcohol use disorder and nicotine intake studies, with research conducted through UNC Health and community partnerships to advance evidence-based addiction treatments.
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