James B. Lorens

James B. Lorens is a Professor at the Department of Biomedicine, Faculty of Medicine, University of Bergen (UiB), Norway. His research is centered on the AXL receptor tyrosine kinase and its pivotal role in cancer progression, therapy resistance, and immune modulation.

Research Interests:

• AXL signaling in tumor cell plasticity and metastasis
• Epithelial-mesenchymal transition (EMT) and stemness
• Metabolic reprogramming in cancer
• Immune evasion and resistance to checkpoint inhibitors
• Angiogenesis and stromal interactions in the tumor microenvironment
• Functional genomics and high-throughput screening

His recent publications (2021–2025) demonstrate a consistent focus on AXL as a central node in cancer signaling, particularly in modulating immune responses, driving metastasis, and conferring resistance across multiple cancer types including lung, breast, pancreatic, and renal cancers. The studies employ advanced models such as 3D spheroids, organoids, and in vivo systems, often integrating high-dimensional single-cell analysis and functional screening.

Scientific Awards:

• No specific awards mentioned in the provided text.

Advising and Grants:
James B. Lorens has supervised numerous PhD and master’s students, as evidenced by his role in multiple doctoral dissertations and theses. His work is highly collaborative, involving extensive co-authorship networks across institutions. While specific grant details are not listed, the sustained output and leadership in multiple research areas suggest active grant funding and project leadership.

Labs and Teams:
He is associated with the research groups 'Metabolism and Cancer' and 'Cellular Networks' at UiB, indicating leadership in interdisciplinary teams focused on cancer signaling and systems biology.