Jacqueline Hirschi

Jacqueline Hirschi is a Professor at ETH Zürich's Institute for Pharmaceutical Sciences, holding the Professorship for Pharmaceutical Chemistry. Her research focuses on metal ion homeostasis (zinc and manganese) and its implications in metabolic and neurological disorders. She employs in vitro and in vivo models, including Zip14 knockout mice, to study zinc's role in intestinal barrier function, insulin secretion, and hepatic glucose metabolism, as well as manganese's detoxification pathways and neurodegenerative associations.

Key research areas include zinc-mediated metabolic endotoxemia, manganese-induced neuroinflammation, and the interplay between ZIP14 transporters and systemic inflammation. Her work bridges molecular mechanisms with translational insights into metabolic and neurodegenerative diseases.

Dr. Hirschi's contributions address how disrupted metal transport impacts chronic inflammation, insulin resistance, adiposity, and neurodegeneration, with implications for therapeutic strategies targeting these pathways.