Jacob Sieg

Jacob Sieg is a Postdoctoral Scholar in the Makova Lab at the Department of Biology, Pennsylvania State University. His work focuses on RNA thermodynamics, genome-wide RNA structure analysis, and the role of metal ions and metabolites in RNA folding and stability.

Research Interests:

• RNA Folding and Thermodynamics
• Metal Ion Interactions in RNA
• RNA-Thermometer Regulation
• Genome-Wide RNA Structure Analysis
• RNA Condensates and Assembly
• RNA Stability in Stress Conditions

Recent work includes the development of MeltR software for nucleic acid thermodynamics analysis and in vivo RNA folding models corrected for metabolite-rich environments. Key publications address RNA structural dynamics, metal ion coordination, and RNA-based virulence regulation in pathogens like Shigella dysenteriae.

Contact: jus841@psu.edu