About
J Patrick Loria is a Professor of Chemistry and of Molecular Biophysics and Biochemistry at Yale University's School of Medicine. His primary appointment is in the Department of Chemistry with a secondary appointment in Molecular Biophysics and Biochemistry. He is affiliated with several research groups including Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS), and the Yale Combined Program in the Biological and Biomedical Sciences (BBS).
Education:
- NIH Postdoctoral Fellow, Columbia University (2000)
- PhD in Biochemistry, University of Notre Dame (1996)
- BS in Chemistry, George Washington University (1990)
Professor Loria's research focuses on the dynamic aspects of protein structure and function, with particular emphasis on enzyme mechanisms and protein folding. His work integrates biophysical techniques, particularly NMR spectroscopy, to investigate how protein motions relate to biological function. His laboratory has made significant contributions to understanding the relationship between protein dynamics and enzyme catalysis, exploring how molecular motions influence enzymatic activity and specificity.
His recent publications demonstrate a consistent focus on protein dynamics and enzyme function, with increasing sophistication in analyzing complex protein motions using NMR techniques. The research spans fundamental biochemical questions about enzyme mechanisms to more applied studies of protein structure-function relationships.
Scientific Awards:
- Camille and Henry Dreyfus New Faculty Fellow
- Alfred P. Sloan Fellowship
Professor Loria has maintained a productive research program with consistent publication output spanning nearly two decades. His work has been supported by various funding mechanisms that have enabled his research on protein dynamics and enzyme function. He collaborates extensively with researchers both within Yale and at other institutions, reflecting the interdisciplinary nature of his work at the interface of chemistry, biophysics, and biochemistry.
His laboratory serves as a training ground for graduate students and postdoctoral researchers interested in the physical aspects of biological systems, emphasizing rigorous quantitative approaches to understanding biomolecular structure and function.
