Ian B. Seiple

Ian B. Seiple is a Professor in the Department of Chemistry at The Scripps Research Institute. His research focuses on developing novel synthetic methods to combat antibiotic resistance, expand antibiotic spectra, and explore targeted protein degradation for cancer therapy. Collaborations span structural biology (e.g., Fraser Lab Cryo-EM studies), drug delivery (DeGrado/Craik Labs), and microscopy innovation (Huang Lab). He leads a lab with expertise in medicinal chemistry and has pioneered tools like CRISPRi-based antibiotic screening and high-resolution Expansion Microscopy.

Education: B.S. from UC Berkeley (2006), Ph.D. from Scripps (2011), postdoc at Harvard (2015). Awards include the Packard Fellowship, Beckman Young Investigator Award, and multiple NIH/NIGMS grants. Teaching recognition includes three UCSF Dean's Apple Awards.

Research Interests: Antibiotic development (streptogramins, lankacidins), Gram-negative pathogen targeting, cancer protein degradation via antibodies, microscopy resolution breakthroughs, and data-driven analysis of scientific authorship gender disparities.

Key Collaborations: Fraser (structural biology), DeGrado/Craik (drug delivery), Huang (microscopy), Rosenberg (high-throughput screening), Wells (protein degradation).