Hugues Roest Crollius

Hugues Roest Crollius is a leading researcher in genomics and evolutionary biology at the École Normale Supérieure (ENS) within the Institute of Biology of ENS (IBENS). He heads the Dynamics and Organization of Genomes team at the Center for Computational Biology (CBC), focusing on comparative genomics, ancestral genome reconstruction, and functional genomics. His work integrates computational methods to study vertebrate genome evolution, including the analysis of conserved non-coding regions and the impact of whole-genome duplications.

Key projects include developing tools like Genomicus for comparative genome analysis and reconstructing ancestral genomes to understand evolutionary processes. He leads collaborations across genomics platforms and contributes to initiatives like the ATLASea program to study marine biodiversity through genomic sequencing. His research bridges computational approaches with experimental biology, addressing questions about genome architecture, regulatory elements, and evolutionary mechanisms.

Publications highlight advancements in ancestral genome reconstruction, teleost evolution, and functional genomics. Roest Crollius actively participates in interdisciplinary training, contributing to computational biology education and mentoring in IBENS programs. His work has implications for understanding genetic diseases and evolutionary processes in vertebrates.