Hugo Fernandes

Hugo Fernandes is a Junior Research Fellow and Group Leader in the Department of Physiology, Anatomy and Genetics at the University of Oxford. He leads a research group focused on understanding early neuronal dysfunction in Parkinson’s and Alzheimer’s diseases, utilizing patient-derived stem cell models to explore lipid dysfunction as a disease mechanism. His work aims to identify novel therapeutic targets to improve patient outcomes. Fernandes holds a DPhil in Neurodegeneration from the University of Oxford (2014) and is affiliated with the Kavli Institute for Nanoscience Discovery.

His research interests emphasize stem cell-based disease modeling, lipid metabolism in neurodegeneration, and the application of advanced omics technologies. Key focuses include proteostasis disruptions, mitochondrial dysfunction, and the interplay between genetic mutations (e.g., GBA1, MAPT) and cellular stress pathways.

Recent publications highlight his team’s exploration of CRISPR-based genetic screens, single-cell omics, and neuroprotective interventions. Their studies reveal novel insights into lipid dysregulation, ER stress, and therapeutic candidates like KAT2B inhibitors. While no formal students are listed, his group actively contributes to collaborative projects in neurodegenerative disease research.

Fernandes’ work integrates molecular, cellular, and systems-level approaches to bridge basic science and clinical translation, with a focus on developing precision medicine strategies for Parkinson’s disease.