Hong S. Lu

Hong S. Lu, MD, PhD, is an Associate Professor at the University of Kentucky, affiliated with the Department of Physiology and the Saha Cardiovascular Research Center. His work focuses on cardiovascular diseases, particularly atherosclerosis and aortic aneurysms, with an emphasis on renin-angiotensin system mechanisms and genomic editing strategies. He collaborates with institutions including Baylor College of Medicine and University of Maryland.

• Doctor of Philosophy, Kanazawa University (2003)
• Doctor of Medicine, Zhejiang University (1993)

His research explores pharmacological inhibition of angiotensinogen, Lipoprotein regulation, and vascular biology of receptors like LRP1 and PAI-1. Current projects include studying Etv5-mediated elastic fiber generation in aortic dissection and myeloid thrombospondin-1 roles in ECM suppression.

Recent grants supported by the American Heart Association and National Heart, Lung, and Blood Institute address cardiovascular system heterogeneity and myocardial infarction models. Awards include ATVB Top Reviewer (2014, 2016) and New Investigator Travel Awards (2004, 2006).

His 160+ research outputs since 2004 span topics like mouse models of coronary atherosclerosis, metformin effects on aneurysms, and complement component 4 suppression in liver steatosis. Collaborations with Dr. Alan Daugherty and others drive innovations in vascular pathology and cardiometabolic disease research.