Hiroko Shike

Hiroko Shike is an Associate Professor in the Department of Pathology and Laboratory Medicine at Penn State University's College of Medicine, affiliated with the Penn State Cancer Institute. Her work focuses on clinical pathology and next-generation sequencing applications.

• Department: Pathology and Laboratory Medicine
• Division: Clinical Pathology
• Institute: Penn State Cancer Institute

Research Interests:

• Immunology and chimerism in stem cell transplantation
• Next-generation sequencing for HLA typing and chimerism testing
• Development of cytotoxic lymphocyte therapies for leukemia
• Comparative analysis of chimerism testing methodologies

Publication Trends: Recent work emphasizes next-generation sequencing (NGS) as a transformative tool in clinical pathology, particularly for monitoring chimerism post-transplantation, improving donor lymphocyte infusion outcomes, and developing dendritic cell-engineered therapies for hematological malignancies. Her research bridges immunological analysis with precision diagnostics.

Laboratories & Collaborations: Dr. Shike collaborates extensively within the Penn State Cancer Institute and with international researchers on projects related to allogeneic stem cell transplantation, graft-versus-host disease, and hematological malignancies.