Henry N. Higgs

Henry N. Higgs is a Professor of Biochemistry and Cell Biology at the Geisel School of Medicine, Dartmouth College, holding the John LaPorte Given Professorship in Cytology. His lab investigates actin dynamics in mammalian cells, particularly focusing on ER-associated actin bursts and mitochondria-stress-induced ADA structures.

• Education: B.A. (Lafayette College, 1987), Ph.D. (University of Washington, 1996), Post-Doc (Salk Institute, 2001)
• Research: Mechanisms of actin polymerization in calcium signaling, mitochondrial division, and cancer immunotherapy via glycolytic activation in T cells

Key Findings: Discovery of INF2-mediated actin bursts triggering mitochondrial division, ADA's role in metabolic switching, and therapeutic applications in adoptive T cell therapies. His lab employs live-cell microscopy, biochemical reconstitution, and proteomics to connect cytoskeletal dynamics with organelle function.

Collaborations: Works with Martin Pollak (Beth Israel) and Ed Usherwood (Dartmouth) on cancer metabolism and immunological projects. Participates in NIH-COBRE grants supporting junior faculty development.