Heidi S Feiler

Heidi S Feiler is a Research Professor and Scientific Program Manager at the Knight Cancer Institute, Oregon Health & Science University (OHSU). Her work focuses on understanding genomic, transcriptomic, and proteomic mechanisms underlying breast and pancreatic cancers' progression and therapeutic responses. She investigates how molecular abnormalities drive cancer pathophysiology and resistance to treatments, aiming to develop strategies for early detection of aggressive cancers and more effective therapies.

Her research integrates multi-omic approaches, including spatial and longitudinal analyses, to study tumor evolution and therapeutic adaptation. Notable contributions include identifying resistance mechanisms to CDK4/6 inhibitors in breast cancer and defining subtypes of pancreatic and ovarian carcinomas with distinct therapeutic responses. She has led collaborative projects like the NIH-funded Library of Integrated Network-Based Cellular Signatures (LINCS) program, cataloging cellular responses to perturbations.

Feiler's work spans drug sensitivity profiling, systems biology modeling, and genomic characterization of glioblastoma. Her studies often involve large-scale datasets and interdisciplinary teams, emphasizing translational applications for precision oncology.