Guoying Bing

Guoying Bing is a Professor in the Department of Neuroscience at the University of Kentucky's College of Medicine. Her research focuses on neuroinflammatory mechanisms in neurodegenerative diseases, particularly Parkinson's disease (PD) and Alzheimer's disease (AD).

• Institution: University of Kentucky, College of Medicine
• Department: Neuroscience
• Academic Rank: Professor

Research Interests: Dr. Bing investigates how microglial activation and xenobiotic metabolites contribute to dopaminergic cell death in PD models, and the role of microsomal epoxide hydrolase (mEH) in neurodegeneration. Current work explores mitochondrial dysfunction, oxidative stress, and neuroinflammatory pathways.

Publication Trends: Recent studies examine neurotoxicity from environmental chemicals (e.g., trichloroethylene, chlorpyrifos), glial-neuronal interactions, and therapeutic agents like pioglitazone and ginsenosides. Keywords span Mitochondrial Bioenergetics, Neuroinflammation, and Xenobiotic Metabolism.

Laboratory Work: Her lab has developed LPS injection models for PD and studied mEH's dual role in activating/inactivating neurotoxic compounds. Collaborative studies involve neurodegenerative signaling pathways (e.g., NF-κB, JNK, PPARγ) and neuroprotective strategies.