Gregory Handy

Gregory Handy is an Assistant Professor at the School of Mathematics, University of Minnesota. His research focuses on bridging applied mathematics with neuroscience through computational modeling and theoretical frameworks. He actively collaborates with experimentalists to develop minimal yet powerful mathematical models for biological systems.

• Current affiliations: Mathematics Department, Biomedical Engineering PhD Program
• Research themes: Cortical network dynamics, Astrocyte calcium signaling, Receptor kinetics, Direction selectivity in auditory cortex

Gregory Handy's work explores how interneuron subpopulations (PV, SOM, VIP) and glial cells modulate cortical network dynamics, particularly in sensory processing. His mathematical models have revealed novel insights about:

• Role of store-operated calcium channels in astrocytes
• Impact of receptor recharge time on neurotransmitter capture
• Mechanisms for direction selectivity in auditory cortex
• Feedback regulation between astrocytes and neurons

His publications demonstrate a consistent focus on mathematical neuroscience with interdisciplinary applications spanning from microscopic receptor kinetics to macroscopic network behavior. The work employs both analytical techniques and computational simulations to uncover fundamental principles of brain function.

As an educator, he mentors graduate students across multiple programs (Mathematics PhD, Biomedical Engineering PhD) and occasionally accepts undergraduate researchers. His lab maintains active funding for projects in theoretical neuroscience and mathematical biology.