Gregoire RONDELET

Gregoire RONDELET is a structural biologist and medicinal chemistry researcher with a focus on DNA methyltransferases, histone modifications, and epigenetic cancer therapy. His work spans enzyme inhibition, molecular modeling, and structural characterization of bioactive compounds. He has led and contributed to projects on non-nucleoside inhibitors and FXIIa-targeting anticoagulants.

• Education: PhD in Sciences (2016) with a thesis on non-nucleoside DNA methyltransferase inhibitors
• Collaborations: Recurring collaborations with J. Wouters, T. Dal Maso, L. Willems

Rondelet’s research interests include:

• DNA Methylation and Epigenetics
• Structural basis of enzyme inhibition
• Crystallographic characterization of drug candidates
• Structure-activity relationships in medicinal chemistry
• Targeting histone-DNA interactions in cancer

His publications highlight trends in:

• Non-nucleoside inhibitors of DNA methyltransferases
• Coumarin-based anticoagulants
• Protein-nucleosome interactions
• X-ray crystallography of bioactive molecules
• Epigenetic therapy for hematological malignancies

Scientific awards include:

• Best Communication Prize (2015)
• Recognition for epigenetic therapy research in ATLL (2015)