Giovanni Manfredi

Giovanni Manfredi, M.D., Ph.D., is the Finbar and Marianne Kenny Professor in Clinical and Research Neurology at Weill Cornell Medicine's Graduate School of Medical Sciences. Affiliated with the Feil Family Brain and Mind Research Institute and the Mitochondria and Neurodegeneration Lab, his work spans mitochondrial biology, neurodegenerative disease pathogenesis, and metabolic stress responses.

• Over 150 publications on mitochondrial dysfunction in ALS and mtDNA mutation diseases
• NIH/NINDS-funded research for >20 years
• Key methodologies: cybrid cell models, patient-derived iPSCs, transgenic mouse models
• Research themes: post-translational protein modifications, mitophagy, calcium homeostasis, metabolic rewiring

His recent studies (2022-2024) reveal novel connections between CHCHD10/CHCHD2 mutations and neurodegeneration, demonstrate sex-dependent mitochondrial responses, and identify metabolic adaptations in mtDNA mutation carriers. Collaborative projects explore antioxidant therapies, mitochondrial proteostasis, and cross-organ metabolic communication in disease states.

Publications show interdisciplinary focus across mitochondrial bioenergetics, ALS/FTD, cardiometabolic disease, and neuroprotective pharmacology, with emerging work on metabolic-epigenetic interactions and mitochondrial stress response networks.

Current initiatives include investigating mitochondrial import mechanisms for mutant proteins, multi-organ metabolic coordination, and translational approaches to restore OXPHOS function in neurodegenerative disorders.