George Sutphin

George Sutphin is an Assistant Professor in the Department of Molecular & Cellular Biology and a member of the Bio5 Institute at the University of Arizona. His research focuses on understanding aging mechanisms and identifying interventions that extend healthy lifespan. He uses Caenorhabditis elegans and mammalian models to study the role of tryptophan metabolism, stress responses, and metabolic pathways in aging. His lab develops high-throughput imaging platforms and genomic tools to analyze aging-related processes. Key areas of interest include kynurenine pathway modulation, proteostasis networks, and cross-species longevity mechanisms.

Dr. Sutphin’s work integrates molecular genetics, biochemical assays, and computational biology to investigate how environmental and genetic factors influence aging. Recent studies highlight the therapeutic potential of metabolites like 3-hydroxyanthranilic acid in mitigating age-related decline in immunity and neurodegeneration. His research also explores the impact of combined stressors on lifespan and the development of novel screening tools for pro-longevity drugs.

His lab is located in the Bioscience Research Laboratory, with office spaces in Life Sciences South and the Bioscience Research Laboratory. He maintains a lab website detailing ongoing projects and collaborations. Research contributions span from fundamental aging mechanisms to translational applications in healthspan extension.