Gavin Kelsey

Dr. Gavin Kelsey leads the Epigenetics Programme at Cambridge Reproduction, focusing on how maternal epigenetic inheritance impacts offspring health. His work explores DNA methylation dynamics in oocytes, environmental influences on epigenetic reprogramming, and mechanisms of genomic imprinting.

• University of Cambridge
• Cambridge Reproduction network member
• Centre for Trophoblast Research affiliation

Research spans epigenetic reprogramming during gametogenesis, single-cell profiling of oocyte methylation, and maternal physiological impacts on embryo development. Key areas include:

• DNA methylation establishment in non-dividing oocytes
• Leptin signaling in ovarian dysfunction
• Species-specific imprinting mechanisms
• Transgenerational epigenetic inheritance
• Epigenetic biomarkers for reproductive outcomes

Pioneering single-cell epigenomic techniques to study preimplantation development, with applications in assisted reproductive technologies and obesity-related infertility. Collaborative work extends to common variable immunodeficiency and neurodegenerative epigenetics.