Gabriele Cruciani

Gabriele Cruciani is a Professor at the University of Perugia's Department of Chemistry, Biology and Biotechnology, leading the research group focused on pharmaceutical compound design, synthesis, and characterization through integrated experimental and computational methodologies.

His research spans:

• Target identification via protein-protein comparison and molecular docking
• Hit-to-lead optimization using virtual screening and ADMET prediction
• Synthesis of drug-like molecules and PROTACs for targeted protein degradation
• Metabolic stability assessment across biological matrices (hepatocytes, microsomes)
• Safety profiling via metabolomics, lipidomics, and HRLC-MS/MS analysis
• High-content imaging for subcellular toxicity mechanisms

No scientific awards were documented in source materials. The laboratory maintains organic synthesis capabilities and advanced instrumentation including the Operetta CLS high-content imaging system with Harmony software for mechanistic safety studies.