Gabriel Loeb

Gabriel Loeb, MD, PhD is an Assistant Professor at the University of California, San Francisco (UCSF) School of Medicine, where he operates as a physician-scientist specializing in genetic kidney diseases. His research integrates human genetics, genomics, and novel kidney disease models to identify molecular mechanisms in chronic kidney disease and Autosomal Dominant Polycystic Kidney Disease (ADPKD). Clinically, he focuses on familial and genetic kidney disease care at the UCSF Nephrology Faculty Practice.

Education

• BS in Biology (2005), Stanford University
• MD (2015), Cornell
• PhD in Immunology (2015), Cornell/Rockefeller/Sloan Kettering
• Internal Medicine Residency (2018), Brigham and Women's Hospital/Harvard Medical School
• Nephrology Fellowship (2021), UCSF

Research Interests center on leveraging human genetic variation to decode kidney disease mechanisms, with a focus on ADPKD and tubule epithelial regulatory elements. His work explores cell type-specific genomics, polycystin channel function, and urine multiomics for non-invasive diagnostics.

Recent Publications highlight advancements in ADPKD mechanistic understanding, urine-based liquid biopsies, and genomic deep learning model limitations. Key journals include Nature Genetics, Nature Communications, and bioRxiv.

Grants & Programs

• Laboratory for Genomics Research Innovation Award (2024–2025)
• Physician Scientist Scholars Program, UCSF (2021–2026)