About
Professor Frederick M. Hughson at Princeton University's Department of Molecular Biology leads structural research on intracellular trafficking mechanisms and bacterial quorum sensing. As Director of Undergraduate Studies, he bridges education and discovery across two major research domains:
- Vesicle Transport: Investigating multisubunit tethering complexes (Dsl1, COG) and SNARE/SM protein interactions through X-ray crystallography and cryo-EM, revealing design principles of membrane fusion machinery
- Bacterial Communication: Pioneering structural characterization of autoinducer signaling pathways in Vibrio and Salmonella, with implications for antimicrobial development
His lab's structural insights into SNARE template complexes and LuxO inhibition have reshaped understanding of both trafficking networks and interspecies signaling. With 2015 President's Award for Distinguished Teaching, he mentors future scientists while maintaining collaborations across Princeton's molecular biology, chemistry, and physics departments.
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