Frederick Arnold

Frederick Arnold, PhD, is an Assistant Professor in the Department of WashU Genetics at Washington University in St. Louis. His research focuses on TDP-43 proteinopathies, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD), aiming to uncover mechanisms linking TDP-43 dysfunction to neuronal death and identify therapeutic targets.

Research Interests:

• Investigation of TDP-43 pathology in neurodegenerative diseases
• Alternative polyadenylation (APA) regulation by TDP-43
• Role of MARK3 in tau phosphorylation and AD
• Genetic risk factors (e.g., ATXN3) in ALS
• Development of therapies targeting TDP-43 and ATXN3

Affiliations:

• Neurogenetics & Transcriptomics Group
• Neurodegeneration/HPAN Division