Francoise Raffalli-Mathieu

Francoise Raffalli-Mathieu serves as a Lecturer at Uppsala University's Department of Chemistry - BMC, specializing in biochemical mechanisms of drug metabolism and steroid biosynthesis. Her research integrates enzymology and molecular biology to investigate glutathione transferases and cytochrome P450 systems within the university's biomedical research framework.

Her primary research interests include Biochemistry, Molecular Biology, Enzymology, Toxicology, Pharmacology, Steroid Metabolism, and Gene Regulation. She focuses on RNA-protein interactions (particularly heterogeneous nuclear ribonucleoproteins), steroid double-bond isomerization, and post-transcriptional regulation of xenobiotic-metabolizing enzymes. Her work bridges fundamental enzymology with physiological applications in steroidogenesis and drug metabolism.

Analysis of her 14 publications (1996-2010) reveals consistent exploration of glutathione S-transferase functions in steroid metabolism and hnRNP-mediated regulation of cytochrome P450 genes. Key trends include mechanistic studies of GST A3-3 in progesterone production, CAR receptor induction by artemisinin, and comparative analyses of CYP enzyme regulation during liver injury. Her work demonstrates interdisciplinary integration of enzymology, molecular toxicology, and endocrine pharmacology.