Feng Guo

Feng Guo is a Professor and Department Vice Chair in Biological Chemistry at the University of California Los Angeles, School of Medicine. His research focuses on RNA processing, microRNA biogenesis, and heme biochemistry. He maintains an active laboratory investigating fundamental molecular mechanisms with implications for therapeutic development.

Dr. Guo's primary research interests center on the molecular mechanisms of microRNA processing, particularly the role of heme in DGCR8 protein function. His work spans structural biology, virology (particularly SARS-CoV-2 research), and RNA biochemistry. His lab has made significant contributions to understanding how heme regulates microRNA processing and has recently developed antisense oligonucleotide approaches for targeting viral RNA.

Analysis of Dr. Guo's publication record reveals a consistent research trajectory focused on RNA-protein interactions, with recent emphasis on SARS-CoV-2 therapeutics. His work bridges fundamental biochemistry with translational applications, particularly in viral therapeutics and RNA-targeted drug development. The publications demonstrate expertise in structural biology, biochemical assays, and molecular mechanisms of RNA processing.

Dr. Guo has secured significant research funding, including NIH R01 grants for 'Developing three-dimensional antisense oligonucleotide drugs against COVID-19' (2021-2026) and 'Molecular recognition and regulation in microRNA processing by the DGCR8 protein' (2007-2012). His research has generated numerous high-impact publications in top journals including Nature, Nature Communications, and PNAS.

His laboratory maintains active collaborations with researchers across UCLA and other institutions, particularly in structural biology and virology. The research environment appears to be highly interdisciplinary, combining biochemical, structural, and cellular approaches to address fundamental questions in RNA biology with therapeutic implications.