About
Dr. Felix Randow is a molecular immunologist at the University of Cambridge, affiliated with the Department of Medicine and the Cambridge Immunology Network. His research focuses on cell-autonomous immunity in mammals, exploring how individual cells defend against pathogens through mechanisms like ubiquitin signaling and autophagy. He collaborates with institutions such as the MRC Laboratory of Molecular Biology (CITIID).
- Current research themes include:
- Cell-autonomous defense mechanisms
- Ubiquitin system in pathogen recognition
- Autophagy and mitochondrial dynamics
- Bacterial immune evasion strategies
- Host-pathogen co-evolution
Recent publications highlight his work on galectin-mediated mitochondrial dynamics, bacterial manipulation of ubiquitin ligases (e.g., RNF213), and the role of autophagy receptors like NDP52 in targeting cytosolic pathogens. His team investigates both fundamental immunological principles and translational applications for infectious disease therapies.
Dr. Randow’s lab is part of Cambridge’s interdisciplinary immunology initiatives, contributing to guidelines for autophagy assays and training programs for researchers. Collaborative profiles include Dr. Leo James and Professor Paul Lehner.
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