Fabrizio Pennacchio

Dr. Fabrizio Pennacchio is a Lecturer at the Department of Health Sciences and Technology at ETH Zürich, affiliated with the Professur Angew. Mechanobiologie. His research focuses on mechanobiology, nuclear mechanics, and hematology, particularly investigating the interplay between cellular mechanics, protein interactions, and disease mechanisms.

His work explores platelet functionality in hemophilia treatment, nuclear volume regulation, and the role of chromatin condensates in diseases like Kabuki Syndrome. He has developed methods such as N2FXm for studying nuclear-cytoplasmic volume dynamics and employs computational tools to analyze cell migration and mechanosensing.

His recent articles highlight trends in recombinant Factor VIII interactions with platelets, nuclear mechanobiology, and the impact of tissue fluidification on cancer immunology. These studies bridge basic science with translational applications in biomedical engineering and clinical hematology.

Dr. Pennacchio’s contributions include advancing understanding of mechanical signaling in cells and tissues, with potential implications for therapeutic development and disease modeling.