Evan Noch

Dr. Evan Noch is an Assistant Professor and Director of Physician-Scientist Development in the Department of Neurology at the University of Texas Southwestern Medical Center. He holds dual MD/PhD degrees from Temple University and completed residency and fellowship training at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center. His research focuses on glioblastoma metabolism, synergistic drug-dietary therapies, and overcoming treatment resistance via metabolic pathways. Dr. Noch leads the Noch Lab, which investigates dietary interventions like ketogenic diets and omega fatty acids to improve glioma treatment efficacy. He has received prestigious awards including the Society for Neuro-Oncology Young Investigator Award and NIH K08 funding for his work targeting cysteine and insulin feedback mechanisms in glioblastoma. He actively advocates for physician-scientists through leadership roles in the American Physician Scientists Association and publishes on workforce challenges during the pandemic. His lab integrates basic science with clinical translation to address critical gaps in neuro-oncology therapy.

Education:

• MD/PhD, Temple University - Biomedical Neuroscience (Advisor: Dr. Kamel Khalili)
• Neurology Residency (Research Track), Weill Cornell Medicine
• Neuro-Oncology Fellowship, Memorial Sloan Kettering Cancer Center
• Postdoctoral Training, Weill Cornell Medicine (Advisor: Dr. Lewis Cantley)

Research Interests: Dr. Noch's work targets metabolic vulnerabilities in glioma through:

• Glioblastoma glucose utilization and redox pathways
• Dietary therapies (e.g., ketogenic diet, omega-3/6 fatty acids)
• PI3K pathway inhibition resistance via insulin feedback
• Cysteine-induced mitochondrial toxicity mechanisms
• Therapeutic strategies combining drugs and nutrition

Key Contributions:

• Discovered insulin feedback as a resistance mechanism to PI3K inhibitors
• Showed cysteine's role in glioma cell death via oxidative stress
• Developed dietary approaches to enhance targeted therapies
• Advocates for physician-scientist career development through leadership roles

Awards:

• NIH/NINDS K08 Career Development Award
• Society for Neuro-Oncology/Prime Oncology Young Investigator Award
• Weill Cornell Medicine Excellence in Medical Education Award

Lab Activities: The Noch Lab focuses on translational research to:

• Identify metabolic dependencies in glioma
• Test dietary interventions in preclinical models
• Develop biomarkers for treatment response
• Bridge basic science discoveries to clinical applications