About
Eric Strieter is a Professor in the Department of Chemistry at the University of Massachusetts Amherst, with affiliations in the Graduate Program in Molecular & Cellular Biology. His research focuses on the molecular mechanisms of ubiquitin and ubiquitin-like modifications (UBLs), particularly the enzymatic networks governing their attachment and removal. He investigates E1, E2, and E3 enzymes, deubiquitylating enzymes (DUBs), and their role in disease pathways like cancer and immune disorders.
- PhD: Massachusetts Institute of Technology (2005)
- BS: University of Wisconsin-Madison (1999)
- Postdoctoral Fellowship: American Cancer Society at Harvard Medical School (2009)
His lab integrates organic chemistry, biochemistry, and cell biology to synthesize designer ubiquitin conjugates, develop DUB inhibitors, and characterize ubiquitin chain architecture. Recent work includes branched multispecific proteins and real-time DUB activity assays.
Key awards include the American Cancer Society Postdoctoral Fellowship. Research methods span mass spectrometry, nanopore technology, and computational modeling. Collaborations emphasize structural proteomics and therapeutic enzyme targeting.
