Eli Chapman

Dr. Eli Chapman is a Professor at the University of Florida in the Department of Pharmacology and Therapeutics and the Center for Inflammation Science and Systems Medicine (CISSM). He holds a PhD from The Scripps Research Institute, an MA from Columbia University, and a BS from UC Berkeley. His research focuses on chemical biology approaches to discover small-molecule modulators of cellular quality control machinery, targeting chaperones like HSP70, HSP60/10, and NRF2 for cancer therapy and antibiotics. His lab has published over 90 peer-reviewed papers and secured four patents.

Education:

• PhD in Pharmacology, The Scripps Research Institute (2002)
• MA in Chemistry, Columbia University (1998)
• BS in Chemistry, UC Berkeley (1996)

Research Interests:

• Discovery of isoform-selective HSP70 inhibitors for cancer treatment
• Development of GroEL/ES inhibitors as antibiotics against MRSA
• Targeting NRF2 activators/inhibitors for chemoprevention and cancer therapy

Grants:

• Principal Investigator: Redox and Protein Homeostasis in Arsenic Tumorigenicity (NIEHS, 2024)
• Co-Investigator: NRF Transcription Factors in Environmental Stress and Disease Intervention (NIEHS, 2024)

Labs/Teams: The Chapman Lab at the Herbert Wertheim UF Scripps Institute focuses on drug discovery and cellular quality control mechanisms.